Response: Fospropofol: Pharmacokinetics?

Propofol and fospropofol sedation during bronchoscopy.

We read with interest the excellent editorial by Michael Jantz (January 2009) 1 that nicely summarized the existing data on the safety of propofol for pulmonary endoscopy. We would like to add that propofol also has an excellent record of safety for GI endoscopy. A recently published study documented the safety of propofolassisted sedation in . 500,000 patients undergoing various GI endoscopies...

Caution advised with use of fospropofol.

Correspondence Financial nonfi nancial disclosures: The authors have reported to CHEST that no potential confl icts of interest exist with any companies organizations whose products or services may be discussed in this article . Correspondence to: Daniel Lichtenstein, MD, FCCP, Service de Réanimation Médicale, Hôpital Ambroise-Paré. F-92100 Boulogne (Paris-Ouest), France; e-mail: [email protected]...

The use of fospropofol during bronchoscopy.

The author has reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article. © 2009 American College of Chest Physicians. Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/ misc/reprints.xhtml). Correspo...

Fospropofol: Is there an infusion regimen for propofol equivalence?

Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol

Fospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release active propofol, formaldehyde, and phosphate. Pharmacodynamic studies show fospropofol provides clinically useful sedation and EEG/bispectral index suppression while causing significantly less respiratory depression than propofol. Pain at the injection site, a common complaint...